Methods for the treatment of thrombosis

Details Methods for the treatment of thrombosis Methods for the treatment of thrombosis

A - Human Necessities

61

K

A61K 31/60 (2006.01) A61K 33/30 (2006.01)

Patent

CA 2215336

Patients having a predisposition for thrombus formation are effectively treated with compositions of acetylsalicylic acid and citric acid, and optionally a zinc salt. The combination of aspirin and citric acid has been found to be significantly more effective in inhibiting platelet aggregability than aspirin alone. Accordingly, new methods and compositions are disclosed for reducing the thrombotic potential of human or animal subjects, such as in the prophylaxis or treatment of atherosclerosis, vascular surgery patients or other cardiovascular diseases.

On traite de façon efficace des patients présentant une prédisposition à la formation de thrombus, avec des compositions comprenant de l'acide acétylsalicylique et de l'acide citrique, ainsi que, le cas échéant, un sel de zinc. L'association d'aspirine et d'acide citrique s'est avérée être notablement plus efficace dans l'inhibition de l'agrégabilité plaquettaire que l'aspirine seule. En conséquence, on décrit des nouvelles méthodes et compositions destinées à réduire le potentiel thrombotique de l'homme ou de l'animal, à titre prophylactique ou de traitement, dans l'athérosclérose, chez des patients en chirurgie vasculaire ou dans d'autres maladies cardio-vasculaires.

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