Method of pulmonary administration of an agent

Details Method of pulmonary administration of an agent Method of pulmonary administration of an agent

A - Human Necessities

61

K

A61K 9/127 (2006.01) A61K 9/72 (2006.01)

Patent

CA 2527625

A method for administering a therapeutic or diagnostic agent to a subject is described. The method includes providing a suspension of liposomes comprised of one or more of vesicle-forming lipids selected from (i) a vesicle-forming lipid derivatized with a hydrophilic polymer and (ii) a neutral lipopolymer, said liposomes being associated with said therapeutic or diagnostic agent, forming an aerosol of said liposome suspension; and administering the aerosol to the subject by inhalation. The liposome formulation delivers intact liposomal particles to the respiratory tract of said subject to form a depot of therapeutic agent therein with no observable provocation of an immune response, as measured by neutrophil or macrophage cell count in the lung after administration.

L'invention concerne une méthode d'administration d'un agent thérapeutique ou diagnostique à un sujet. Cette méthode consiste : à prévoir une suspension de liposomes comprenant un ou plusieurs lipides formant des vésicules, choisis parmi (i) un lipide formant une vésicule dérivée d'un polymère hydrophile et (ii) un lipopolymère neutre, lesdits liposomes étant associés audit agent thérapeutique ; à former un aérosol à partir de ladite suspension de liposomes ; et à administrer l'aérosol au sujet par inhalation. Le produit formulé à base de liposomes délivre des particules liposomales dans les voies respiratoires dudit sujet pour former un dépôt d'agent thérapeutique dans ce dernier, sans provocation observable d'une réponse immunitaire, d'après une mesure par dénombrement de cellules macrophages ou neutrophiles dans le poumon après l'administration.

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