Bipiperidinyl derivatives useful as inhibitors of chemokine...

Details Bipiperidinyl derivatives useful as inhibitors of chemokine... Bipiperidinyl derivatives useful as inhibitors of chemokine...

C - Chemistry, Metallurgy

07

D

C07D 401/14 (2006.01) A61K 31/445 (2006.01) A61P 9/02 (2006.01) A61P 11/06 (2006.01) A61P 17/06 (2006.01) A61P 31/18 (2006.01)

Patent

CA 2544377

In its many embodiments, the present invention provides a novel class of bipiperidinyl compounds as inhibitors of the CCR5 receptors, methods of preparing such compounds, pharmaceutical compositions containing one or more such compounds, methods of preparing pharmaceutical formulations comprising one or more such compounds, and methods of treatment, prevention, inhibition, or amelioration of one or more diseases associated with CCR5 using such compounds or pharmaceutical compositions. The invention also relates to the use of a combination of a compound of this invention and one or more antiviral or other agents useful in the treatment of Human Immunodeficiency Virus (HIV). The invention further relates to the use of a compound of this invention, alone or in combination with another agent, in the treatment of solid organ transplant rejection, graft v. host disease, arthritis, rheumatoid arthritis, inflammatory bowel disease, atopic dermatitis, psoriasis, asthma, allergies or multiple sclerosis.

Dans ses nombreux modes de réalisation, l'invention concerne une nouvelle classe de composés de bipiperidinyl utilisés comme inhibiteurs des récepteurs CCR5, des procédés de préparation desdits composés, des compositions pharmaceutiques comprenant un ou plusieurs de ces composés, des procédés de préparation de formulations pharmaceutiques comprenant un ou plusieurs de ces composés et des méthodes permettant de traiter, de prévenir, d'inhiber ou d'améliorer une ou plusieurs maladie(s) associée(s) à CCR5 à l'aide de ces composés ou compositions pharmaceutiques. L'invention concerne également l'utilisation d'une combinaison d'un composé de l'invention et d'un ou plusieurs agent(s) antiviral/raux ou autres pour traiter le virus de l'immunodéficience humaine (VIH). L'invention concerne enfin l'utilisation du composé de l'invention seul ou combiné à un autre agent pour traiter le rejet d'une transplantation d'organe solide, une greffe par rapport à une maladie de l'hôte, l'arthrite, l'arthrite rhumatoïde, les maladies intestinales inflammatoires, la dermatite atopique, le psoriasis, l'asthme, les allergies ou la sclérose en plaques.

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