C - Chemistry – Metallurgy – 07 – C
Patent
C - Chemistry, Metallurgy
07
C
C07C 51/41 (2006.01) A61K 31/19 (2006.01) A61P 25/06 (2006.01) A61P 25/08 (2006.01) C07C 53/128 (2006.01)
Patent
CA 2387958
The invention relates to a method for producing compounds which contain at least one molecule valproinic acid salt and at least one molecule valproinic acid. The valproinic acid salt represents alkali or alkaline earth salt. Valproinic acid is directly converted with the calculated amount of the corresponding alkali carbonate or earth alkaline carbonate and/or the calculated amount of the corresponding alkali bicarbonate or earth alkaline bicarbonate without adding a solvent and at a temperature that is higher than the melting temperature of valproinic acid.
L'invention concerne un procédé de production de composés qui contiennent au moins une molécule de sel d'acide valproïque et au moins une molécule d'acide valproïque, le sel d'acide valproïque étant un sel alcalin ou alcalino-terreux. Selon ledit procédé on fait réagir l'acide valproïque, sans addition de solvant et à une température supérieure à la température de fusion de l'acide valproïque, directement avec une quantité calculée du carbonate alcalin ou du carbonate alcalino-terreux correspondant et/ou une quantité calculée du bicarbonate alcalin ou du bicarbonate alcalino-terreux correspondant.
Blake Cassels & Graydon Llp
Cilag Ag
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