C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
C12N 1/20 (2006.01) C12P 7/40 (2006.01) C12P 33/00 (2006.01)
Patent
CA 2212186
Bacillus Sp. TTUR 302 which belongs to the genus Bacillus and is capable of converting bile acids having a 7.alpha.-hydroxyl group or a 7-keto group intobile acids having a 7.beta.-hydroxyl group; and a process for producing bile acids having a 7.beta.-hydroxyl group which comprises incubating this microorganism in an enriched medium containing bile acids having a 7.alpha.-hydroxyl group or a 7-keto group and collecting the formed bile acids having a 7.beta.-hydroxyl group (ursodeoxycholic acids, etc.). The process is easy to operate and safe as compared with the conventional chemical synthesis method. It is also superior to the conventional microbial methods particularly in the case of industrial production, since the microorganism of the invention is a facultative anaerobe and thus capable of effecting the conversion of the bile acids under aerobic conditions at a high substrate concentration. Moreover, the microorganism shows neither any hemolytic properties nor lecithinase productivity which might result in pathogenicity. Thus this process is a highly excellent one.
Bacillus Sp. TTUR 302 appartenant au genre Bacillus et capable de convertir des acides biliaires 7alpha-hydroxylés ou 7-cétoniques en acides 7bêta-hydroxylés; méthode pour l'obtention d'acides biliaires 7bêta-hydroxylés, consistant à incuber ce microorganisme dans un milieu enrichi renfermant des acides biliaires 7alpha-hydroxylés ou 7-cétoniques et à recueillir les acides biliaires 7bêta.-hydroxylés formés (acides ursodésoxycholiques, etc.). Le procédé est facile à appliquer et sans risque, comparativement à la méthode de synthèse chimique classique. Il est supérieur aussi aux méthodes microbiennes classiques, particulièrement dans le cas de la production industrielle, en effet le microorganisme de l'invention est un anaérobie facultatif et, par conséquent, capable d'effectuer la conversion des acides biliaires à des concentrations aérobies et à forte concentration dans le substrat. De plus, le microorganisme ne présente ni propriétés hémolytiques ni productivité de lécithinase, pouvant entraîner une certaine pathogénicité. Le procédé est donc excellent.
Kimura Hiromi
Ogata To-Oru
Okamura Akio
Gowling Lafleur Henderson Llp
Mitsubishi-Tokyo Pharmaceuticals Inc.
Tokyo Tanabe Company Limited
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