Method for differentially detecting multimeric form from...

Details Method for differentially detecting multimeric form from... Method for differentially detecting multimeric form from...

G - Physics

01

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G01N 33/543 (2006.01) C12Q 1/68 (2006.01) G01N 1/28 (2006.01) G01N 1/44 (2006.01) G01N 33/53 (2006.01) G01N 33/58 (2006.01) C07K 16/18 (2006.01)

Patent

CA 2598321

The present invention relates to a method for differentially detecting a multimeric form from a monomeric form of a multimer-forming polypeptide in a biosample, which comprises the steps of: (a) contacting the biosample to a capturing antibody recognizing an epitope on the multimer-forming polypeptide to capture the monomeric form, multimeric form or monomeric and multimeric forms; (b) contacting the monomeric form, multimeric form or monomeric and multimeric forms captured to a detecting antibody recognizing an epitope identical to or overlapped with the epitope of step (a); and (c) detecting the formation of a multimeric form-detection antibody complex.

La présente invention concerne un procédé de détection différentielle d'une forme multimère à partir d'une forme monomère d'un polypeptide formant des multimères dans un échantillon biologique, lequel procédé comprend les étapes consistant: (a) à mettre l'échantillon biologique en contact avec un anticorps de capture reconnaissant un épitope sur le polypeptide de formation de multimères pour capturer la forme monomère, la forme multimère ou les formes monomère et multimère; (b) à mettre la forme monomère, la forme multimère ou les formes monomère et multimère capturés en contact avec un anticorps de détection reconnaissant un épitope identique à l'épitope de l'étape (a) ou recouvert par celui-ci; et (c) à détecter la formation d'un complexe forme multimère-anticorps de détection

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