C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 417/06 (2006.01) A61K 31/506 (2006.01) A61P 25/00 (2006.01) C07D 277/64 (2006.01) C07D 403/06 (2006.01) C07D 413/06 (2006.01) C07D 417/14 (2006.01) C07D 521/00 (2006.01)
Patent
CA 2394809
The present invention is related to benzazole derivatives accord-ing to formula (I) wherein X is O, S, or NR O with R0 being H or an unsubstituted or substituted C1-C6alkyl, and G is an unsubstituted or substituted pyrimidinyl group, notably for use as pharmaceutically active compounds, as well as to phar-maceutical formulations containing such benzazoles derivatives. Said benzazoles derivatives are efficient modulators of the JNK pathway, they are in particular ef-ficient and selective inhibitors of JNK2 and/or 3.
La présente invention concerne des dérivés de benzazole représentés par la formule (I) dans laquelle, X est O, S ou NR?0¿, avec R?0¿ étant H ou un alkyle en C¿1?-C¿6? Non substitué ou substitué; et G est un groupe pyrimidinyle non substitué ou substitué. Ces dérivés sont utilisés en tant que composés pharmaceutiquement actifs. L'invention concerne également des formulations pharmaceutiques renfermant de tels dérivés de benzazole. Lesdits dérivés sont des modulateurs efficaces de la voie JNK ainsi que des inhibiteurs particulièrement efficaces et sélectifs de JNK2 et/ou 3.
Camps Montserrat
Church Dennis
Gaillard Pascale
Gotteland Jean-Pierre
Halazy Serge
Applied Research Systems Ars Holding N.v.
Kirby Eades Gale Baker
Merck Serono Sa
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