C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
C12N 15/86 (2006.01) A61K 48/00 (2006.01) C07K 14/115 (2006.01) C07K 14/145 (2006.01) C12N 7/01 (2006.01) C12N 15/40 (2006.01) C12N 15/62 (2006.01)
Patent
CA 2316033
This invention relates to a composition comprising a recombinant or genetically engineered Rhabdovirus that expresses a Fusion Protein, such as the F protein of the Paramyxovirus SV5 strain. This recombinant Rhabdovirus may express other non-Rhabdovirus attachment proteins and/or an enhancer protein. The invention also relates to methods of making recombinant Rhabdoviruses which express an F Protein. These recombinant compositions can be used for purposes of research, as well as for diagnostic and therapeutic compositions for treatment of diseases.
L'invention a trait à une composition comportant un rhabdovirus mis au point génétiquement ou recombiné qui exprime une protéine de fusion telle que la protéine F de la souche Paramyxovirus SV5. Ce rhabdovirus recombiné peut exprimer d'autres protéines de fixation non rhabdovirus et/ou une protéine amplificatrice. L'invention a également trait à des procédés de fabrication de rhabdovirus recombinés qui expriment une protéine F. Ces compositions recombinées peuvent être utilisées à des fins de recherche, ainsi que dans des compositions diagnostiques et thérapeutiques pour traiter des maladies.
Robison Clinton S.
Whitt Michael A.
Riches Mckenzie & Herbert Llp
The University Of Tennessee Research Corporation
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