C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
C12N 1/19 (2006.01) C12N 9/00 (2006.01) C12P 7/64 (2006.01)
Patent
CA 2744716
Described are methods of reducing the amount of byproduct organic acids during fermentation of an organism, based on expression of a heterologous malonyl-CoA synthetase. A polyunsaturated fatty acid ["PUFA"]-producing strain of the oleaginous yeast Yarrowia lipolytica was engineered to express a heterologous malonyl-CoA synthetase gene. The expression did not effect the production of PUFAs, but did result in a reduced amount of malonates when compared to the amount of malonates produced in the parental strain not expressing malonyl-CoA synthetase.
La présente invention concerne des procédés de réduction de la quantité des sous-produits acides organiques formés lors de la fermentation d'un organisme, basés sur l'expression d'une malonyl-CoA synthétase hétérologue. Une souche produisant des acides gras polyinsaturés ["PUFA"] de la levure oléagineuse Yarrowia lipolytica a été génétiquement modifiée pour exprimer un gène de la malonyl-CoA synthétase hétérologue. L'expression n'a pas affecté la production d'acides gras polyinsaturés ["PUFA"], mais a entraîné une réduction de la quantité de malonates comparativement à la quantité de malonates produits dans la souche parentale n'exprimant pas la malonyl-CoA synthétase.
Xue Zhixiong
Zhu Quinn Qun
E.i. Du Pont de Nemours And Company
Torys Llp
LandOfFree
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