Method and system for intravesicular delivery of therapeutic...

Details Method and system for intravesicular delivery of therapeutic... Method and system for intravesicular delivery of therapeutic...

A - Human Necessities

61

L

A61L 27/54 (2006.01) A61F 2/00 (2006.01) A61F 2/04 (2006.01) A61F 2/36 (2006.01) A61F 6/06 (2006.01) A61K 9/00 (2006.01) A61L 27/14 (2006.01) A61L 27/34 (2006.01)

Patent

CA 2503193

A therapeutic agent delivery implant (42) for implantation into a patient's body comprises a resilient or flexible, at least partially hydrophobic reticulated elastomeric support scaffold; and a hydrophilic coating arranged on said scaffold, wherein said coating contains one or more therapeutic agents for release within the patient. Optionally the coating can contain microspheres or enzymes. In a preferred embodiment, the scaffold comprises a hydrophobic polyurethane, the coating comprises a hydrophilic polyurethane, and the implant has a hemispherical, bullet, football, cylindrical, spherical, or irregular shape. The implant can be delivered through a rigid or flexible delivery instrument that deploys the implant at a desirable site, whereby the implant expands to a size and shape substantially similar to its size and shape before insertion.

L'invention porte sur un implant corporel libérant un agent thérapeutique, présentant un squelette d'élastomère réticulé, élastique ou souple, au moins partiellement hydrophobe, et un revêtement hydrophile entourant le squelette, contenant un ou plusieurs agents thérapeutiques se libérant dans le corps du patient, et facultativement des microsphères ou des enzymes. Dans l'exécution préférée le squelette est fait d'un polyuréthane hydrophobe, et l'implant peut présenter une forme hémisphérique, cylindrique, sphérique ou irrégulière. L'implant se met en place via un instrument rigide ou flexible qui le dépose dans le site voulu où il se dilate pour reprendre une taille et une forme sensiblement similaires à celles qu'il présentait avant l'implantation.

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