Treatment and diagnosis of insulin resistant states

Details Treatment and diagnosis of insulin resistant states Treatment and diagnosis of insulin resistant states

C - Chemistry, Metallurgy

12

N

C12N 5/12 (2006.01) A61K 31/175 (2006.01) A61K 31/64 (2006.01) A61K 38/00 (2006.01) A61K 38/17 (2006.01) A61K 38/18 (2006.01) A61K 38/22 (2006.01) A61K 38/28 (2006.01) A61K 45/00 (2006.01) A61P 3/04 (2006.01) A61P 3/10 (2006.01) C07K 14/435 (2006.01) C07K 14/47 (2006.01) C07K 16/18 (2006.01) C12N 5/10 (2006.01) C12Q 1/25 (2006.01) G01N 33/53 (2006.01) G01N 33/537 (2006.01) G01N 33/543 (2006.01) G01N 33/577 (2006.01) G01N 33/68 (2006.01) C12N 15/09 (2006.01) C12P 21/08 (2006.01)

Patent

CA 2461818

Dickkopf-5 (Dkk-5) protein is administered in effective amounts to treat disorders involving insulin resistance, such as non-insulin-dependent diabetes mellitus (NIDDM) or obesity. Also provided is a method of diagnosing insulin resistance and related disorders using Dkk-5 as a measure, and kits for diagnosis and treatment, as well as hybridomas producing antibodies to Dkk-5 and preparations comprising Dkk-5.

On administre, dans le cadre de cette invention, des protéines de Dickkopf-5 (Dkk-5), sous des quantités efficaces, pour traiter des pathologies se traduisant par une résistance à l'insuline, notamment le diabète sucré non insulino-dépendant (DNID) ou l'obésité. L'invention a également trait à une méthode permettant de diagnostiquer une résistance à l'insuline ainsi que des troubles en rapports et ce, à l'aide de Dkk-5 comme outil de mesure. Elle concerne, de surcroît, des nécessaires diagnostiques et thérapeutiques. Elle porte, en outre, sur des hybridomes destinés à produire des anticorps anti Dkk-5 ainsi que sur des préparations contenant les protéines Dkk-5.

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