Organic compounds

C - Chemistry – Metallurgy – 07 – D

Patent

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Details

C07D 241/20 (2006.01) A61K 31/4965 (2006.01) A61K 31/497 (2006.01) A61P 11/00 (2006.01) C07D 401/12 (2006.01)

Patent

CA 2727196

A compound of Formula (I) or a hydrate or solvate thereof, where R 1, R 2, R 3, R 4, R 5, R 6, R 7, R 8, R 9 and R 10 have the meanings as indicated in the specification, is useful for treating diseases which respond to the blockade of the epithelial sodium channel. Pharmaceutical compositions that contain the compounds and processes for preparing the compounds are also described.

L'invention porte sur un composé de formule I ou sur un hydrate ou solvate associé, dans laquelle formule R1, R2, R3, R4, R5, R6, R7, R8, R9 et R10 possèdent les significations telles que définies dans la description, lequel composé est utile pour le traitement de maladies qui répondent au blocage du canal sodique épithélial. L'invention porte également sur des compositions pharmaceutiques qui contiennent les composés et sur des procédés pour la fabrication des composés.

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