Novel drug compositions and dosage forms of topiramate

Details Novel drug compositions and dosage forms of topiramate Novel drug compositions and dosage forms of topiramate

A - Human Necessities

61

K

A61K 9/00 (2006.01) A61K 31/35 (2006.01)

Patent

CA 2564227

The present invention is directed to novel drug compositions and dosage forms comprising said drug compositions. The drug compositions of the present invention comprise a pharmaceutical agent and a solubilizing agent. The drug compositions of the present invention are particularly advantageous for use with low solubility and / or low dissolution rate pharmaceutical agents. The present invention is further directed to methods for manufacturing of said drug compositions: and dosage forms. The present invention is further directed to methods of treatment comprising administration of said drug compositions and dosage forms. The present invention further provides topiramate drug compositions, dosage forms and methods of treatment which provide a reduction in the frequency and / or severity of at least one adverse event associated with topiramate treatment.

L'invention concerne des compositions médicamenteuses et des formes pharmaceutiques renfermant lesdites compositions, lesquelles comportent un agent pharmaceutique et un agent de solubilisation. Ces compostions sont particulièrement avantageuses utilisées avec des agents pharmaceutiques à faible solubilité et/ou faible taux de dissolution. L'invention concerne également des procédés de fabrication des compositions médicamenteuses et formes pharmaceutiques considérées. L'invention concerne en outre des procédés de traitement reposant sur l'administration de ces produits. On décrit par ailleurs des compositions médicamenteuses et des formes pharmaceutiques de topiramate et des procédés de traitement qui assurent une réduction de la fréquence et/ou de la sévérité d'au moins un effet néfaste lié au traitement par topiramate.

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