Recombinant bhlh-pas/jhr polypeptide and its use to screen...

Details Recombinant bhlh-pas/jhr polypeptide and its use to screen... Recombinant bhlh-pas/jhr polypeptide and its use to screen...

C - Chemistry, Metallurgy

12

N

C12N 1/15 (2006.01) C07H 21/04 (2006.01) C07K 14/00 (2006.01) C07K 14/435 (2006.01) C12N 5/10 (2006.01) C12N 15/11 (2006.01) C12N 15/63 (2006.01) C12N 15/81 (2006.01) C12N 15/86 (2006.01)

Patent

CA 2286932

Promising groups of environmetally-safe insecticides consist of analogues of insect hormones, such as juvenile hormone, and antagonists of such hormones. The traditional bioassay approach for screening potential juvenile hormone analogs and antagonists is slow, expensive and inefficient. A recombinant bHLH- PAS-juvenile hormone receptor, isolated from the methoprene-tolerant locus on Drosophila, provides the basis of in vitro and in vivo binding assays that can be used to discover new juvenile hormone-type targeted insecticides. Moreover, the nucleotide sequence of the Drosophila bHLH-PAS/JHR polypeptide provides tools for isolating juvenile hormone receptor genes from other insect species.

Des groupes prometteurs d'insecticides sans danger pour l'environnement, consistent en analogues d'hormones d'insectes, telle que l'hormone juvénile, et en antagonistes desdites hormones. La méthode d'essai biologique classique pour la sélection d'analogues et d'antagonistes de l'hormone juvénile est lente, chère et inefficace. Un récepteur de l'hormone juvénile (JHR) bHLH-PAS recombiné, isolé dans le locus tolérant au méthoprène sur Drosophila (voir Figure 1), constitue la base d'essais de liaison in vitro et in vivo pouvant être utilisés pour la découverte d'insecticides cibles du type hormone juvénile. De plus, la séquence nucléotidique du polypeptide bHLH-PAS/JHR de Drosophila, constitue un outil pour l'isolement de gènes du récepteur de l'hormone juvénile dans d'autres espèces d'insectes.

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