Phosphorylated glyoxalase i and its use

Details Phosphorylated glyoxalase i and its use Phosphorylated glyoxalase i and its use

C - Chemistry, Metallurgy

12

N

C12N 9/88 (2006.01) A61K 38/51 (2006.01)

Patent

CA 2436522

The present invention relates to a phosphorylated form of mammalian glyoxalase I. The present invention relates further to the use of phosphorylated mammalian glyoxalase I to modulate MG-modification of proteins (AGE formation) and consequent cell death, especially upon stress such as oxidative stress, or upon TNF treatment.

La présente invention concerne la forme phosphorylée de la glyoxalase I mammalienne. L'invention concerne également l'utilisation de la glyoxalase I phosphorylée mammalienne pour la modulation de la modification en MG des protéines (formation des AGE) et de l'apoptose qui en résulte, notamment sous conditions de stress tel que le stress oxydatif, ou pour un traitement du facteur de nécrose tumorale.

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