Hiv-inhibiting benzeneacetamide derivatives

Details Hiv-inhibiting benzeneacetamide derivatives Hiv-inhibiting benzeneacetamide derivatives

C - Chemistry, Metallurgy

07

C

C07C 237/20 (2006.01) A61K 31/165 (2006.01) A61K 31/195 (2006.01) A61K 31/24 (2006.01) A61K 31/275 (2006.01) A61K 31/395 (2006.01) C07C 45/00 (2006.01) C07C 49/813 (2006.01) C07C 205/45 (2006.01) C07C 205/57 (2006.01) C07C 237/30 (2006.01) C07C 237/42 (2006.01) C07C 251/48 (2006.01) C07C 251/86 (2006.01) C07C 255/42 (2006.01) C07C 255/44 (2006.01) C07C 255/57 (2006.01) C07C 255/60 (2006.01) C07C 327/44 (2006.01)

Patent

CA 2084508

2084508 9200952 PCTABS00010 A compound for use as a medicine having formula (I), a pharmaceutically acceptable acid addition salt form or a stereochemically isomeric form thereof, wherein R1 and R2 each independently are hydrogen, C1-6alkyl or C3-6cycloalkyl; or R1 and R2 taken together with the nitrogen atom bearing said R1 and R2 may form a pyrrolidinyl, piperidinyl, morpholinyl, piperazinyl or 4-C1-4alkylpiperazinyl group; X is O or S; R3 is hydrogen or C1-6alkyl; R4, R5 and R6 each independently are hydrogen, halo, C1-6alkyl, C1-6alkyloxy, nitro, trifluoromethyl, cyano, aminomethyl, carboxyl, C1-4alkyloxycarbonyl, C1-4alkyl-carbonyl, aminocarbonyl or hydroxy; R7 is hydrogen or halo; and R8, R9 and R10 each independently are hydrogen, halo, C1-6alkyl, C1-6alkyloxy, nitro, hydroxy, trifluoromethoxy, 2,2,2-trifluoroethoxy, (trifluoromethyl)carbonyl, aminocarbonyl, (cyclopropyl)carbonyl or a radical C1-6alkyl-(C=Y)- wherein =Y represents =O, =N-OH, =N-OCH3, =N-NH2 or =N-N(CH3)2; provided that (1) R1 is other than n-propyl when R2, R3, R4, R5, R6, R7, R9 and R10 represent hydrogen, R8 represents 4-ethoxy and X represents oxygen, and (2) X is other than sulfur, when R1, R2, R3, R6, R7, R8, R9 and R10 represent hydrogen and R4 and R5 represent 3,4-dimethoxy. Novel compounds, pharmaceutical compositions containing said compounds of formula (I), and processes for preparing said compositions.

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