A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 35/12 (2006.01) A61K 35/44 (2006.01) A61K 48/00 (2006.01)
Patent
CA 2369439
The invention provides methods for the treatment of abnormal psychiatric states, particularly the negative symptoms of schizophrenia and extrapyramidal side effects (EPS) of antipsychotic drugs. The inventive methods relate to the administration of therapeutic cells (which produce dopamine or dopamine precursors) adhered to support matrices to subjects suffering from the negative symptoms of schizophrenia and/or EPS. The therapeutic cells may be coadministered with cells which protect the therapeutic cells from immune rejection and/or cells which produce neurotrophic factors which improve the viability of the therapeutic cells.
L'invention concerne des méthodes de traitement d'états psychiatriques anormaux, notamment les symptômes négatifs de la schizophrénie et les effets secondaires extrapyramidaux (EPS) des médicaments antipsychotiques. Les méthodes de l'invention consistent à administrer des cellules thérapeutiques (qui produisent de la dopamine ou des précurseurs de la dopamine) adhérées à des matrices support à des sujets souffrant des symptômes négatifs de la schizophrénie et/ou de l'EPS. Ces cellules thérapeutiques peuvent être coadministrées avec des cellules qui les protègent du rejet immunitaire et/ou avec des cellules qui produisent des facteurs neurotrophiques pouvant améliorer la viabilité des cellules thérapeutiques.
Allen Richard C.
Cornfeldt Michael
Borden Ladner Gervais Llp
Titan Pharmaceuticals Inc.
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