Method of binding recognizing substances to liposomes

Details Method of binding recognizing substances to liposomes Method of binding recognizing substances to liposomes

A - Human Necessities

61

K

A61K 9/127 (2006.01) B01J 13/02 (2006.01)

Patent

CA 2176566

Recognizing substances, including epidermal growth factor, gelatin, collagen and hyaluronic acid, have been covalently bound to liposomal surfaces and utilized to attach liposomes onto a cellular or an extracellular matrix (ECM) target site. These "bioadhesive" liposomes offer several advantages including the mutual protection of both the drug and biological environment; an increase in drug bioavailability and retention at the target site; and improved adherence or adhesion to the designated target site

Des substances de reconnaissance, telles que le facteur de croissance épidermique, la gélatine, le collagène et l'acide hyaluronique, ont été liées de manière covalente à des surfaces liposomiques et utilisées pour fixer les liposomes sur un site cible de matrice cellulaire ou extracellulaire (MCE). Ces liposomes "bioadhésifs" présentent plusieurs avantages dont: la protection mutuelle du médicament et de l'environnement biologique; un accroissement de la biodisponibilité et de la rétention du médicament au niveau du site cible; et une meilleure adhérence ou adhésion au site de cible désigné.

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