A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 31/505 (2006.01) A61K 31/404 (2006.01) A61K 31/517 (2006.01) A61P 25/30 (2006.01) G01N 33/50 (2006.01)
Patent
CA 2477726
The present invention relates to a method for treating substance use disorders, more particularly drug addiction, drug habituation, drug dependence, withdrawal syndrome and overdose, comprising administering a compound capable of depleting mast cells to a human in need of such treatment. Such compounds can be chosen from tyrosine kinase inhibitors and more particularly non-toxic, selective and potent c-kit inhibitors. Preferably, said inhibitor is unable to promote death of IL-3 dependent cells cultured in presence of IL-3.
L'invention concerne une méthode de traitement de troubles liés à l'utilisation de substances, plus particulièrement la pharmacodépendance, la toxicomanie, l'accoutumance, le syndrome de sevrage et l'overdose, consistant à administrer un composé capable de réduire le nombre des mastocytes chez un humain nécessitant un tel traitement. De tels composés peuvent être choisis parmi les inhibiteurs de tyrosine kinase et plus particulièrement parmi des inhibiteurs c-kit puissants, sélectifs et non toxiques. Cet inhibiteur est, de préférence, incapable de favoriser la mort de cellules dépendantes d'IL-3 cultivées en présence d'IL-3.
Kinet Jean-Pierre
Moussy Alain
Ab Science
Smart & Biggar
LandOfFree
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