C - Chemistry – Metallurgy – 12 – Q
Patent
C - Chemistry, Metallurgy
12
Q
C12Q 1/18 (2006.01) C07K 14/18 (2006.01) G01N 33/50 (2006.01) G01N 33/576 (2006.01)
Patent
CA 2604442
The present invention relates generally to replicase complex defect inducers and pharmaceutical compositions containing such inducers. Methods of developing mutants that are resistant to replicase complex defect inducers are also provided. Further included are mutants that can be used in screening for replicase complex defect inducers. Methods of screening test compounds for the ability to induce the formation of replicase complex defects are also described. Also included are methods of inhibition of HCV replication by replicase complex defect inducers.
La présente invention concerne, généralement, des inducteurs de défaut d'un complexe réplicase et des composition pharmaceutiques contenant de tels inducteurs. Ladite invention a aussi pour objet des méthodes de développement de mutants résistants aux inducteurs de défaut du complexe réplicase. Par ailleurs, cette invention a trait à des mutants pouvant être utilisés dans le criblage d'inducteurs de défaut du complexe réplicase et des méthodes de criblage de composés d'essai permettant d'induire la formation de défauts du complexe réplicase. Enfin, l'invention concerne des méthodes d'inhibition de la réplication du VHC par le biais d'inducteurs de défauts du complexe réplicase.
Achillion Pharmaceuticals Inc.
Norton Rose Or S.e.n.c.r.l. S.r.l./llp
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