Resonant optical cavities for high-sensitivity,...

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G01N 33/543 (2006.01) G01N 21/25 (2006.01) G01N 21/55 (2006.01) G01N 21/64 (2006.01)

Patent

CA 2384977

Biosensors including resonant optical cavities. The resonant optical cavities are shaped so as to generate whispering gallery modes, which increase the quality factors of the cavities and facilitate the detection of analytes in a sample with enhanced sensitivity. The sizes of the resonant optical cavities facilitate their use in biosensors that include arrays of sensing zones. Accordingly, the resonant optical cavities may be used in high-density sensing arrays that can be read in real-time and in parallel. Thus, the resonant optical cavities are useful for detecting small concentrations of samples in real-time and with high throughput. Different embodiments of the biosensors are also disclosed, as are methods for using the biosensors.

L'invention concerne des biodétecteurs comprenant des cavités optiques résonnantes. Ces cavités optiques résonnantes ont une forme qui leur permet de générer des modes de voûtes acoustiques qui augmentent les facteurs qualité des cavités et facilite la détection des substances à analyser d'un échantillon avec une plus grande sensibilité. L'utilisation des cavités optiques résonnantes dans des ensembles de détection haute densité pouvant être lus en temps réel et en parallèle est facilitée par leur taille. Ainsi, les cavités optiques résonnantes sont utiles pour la détection de petites concentrations d'échantillons en temps réel et à haut rendement. L'invention concerne également différents modes de réalisation des biodétecteurs ainsi que des procédés utilisant ces biodétecteurs.

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