Bicyclic pyrrolyl amides as glucogen phosphorylase inhibitors

Details Bicyclic pyrrolyl amides as glucogen phosphorylase inhibitors Bicyclic pyrrolyl amides as glucogen phosphorylase inhibitors

C - Chemistry, Metallurgy

07

D

C07D 495/04 (2006.01) A61K 31/407 (2006.01) A61P 3/10 (2006.01) A61P 9/10 (2006.01) C07D 487/04 (2006.01) C07D 491/04 (2006.01) C07D 513/04 (2006.01) C07D 519/00 (2006.01)

Patent

CA 2417594

Heterocyclic amide derivatives, of formula (I): wherein -X-Y-Z- is selected from -S-CR4=CR5-, -CR4=CR5-S-, -O-CR4=CR5-, -CR4=CR5-O-, -N=CR4-S-, -S-CR4=N-, -NR6-CR4=CR5- and -CR4=CR5-NR6-; or a pharmaceutically acceptable salt or an in vivo hydrolysable ester thereof; (with provisos); possess glycogen phosphorylase inhibitory activity and accordingly have value in the treatment of disease states associated with increased glycogen phosphorylase activity. Processes for the manufacture of said heterocyclic amide derivatives and pharmaceutical compositions containing them are described.

Selon l'invention, les dérivés d'amides hétérocycliques de la formule, dans laquelle -X-Y-Z- est sélectionné parmi -S-CR?4¿=CR?5¿-, -CR?4¿=CR?5¿-S-, -O-CR?4¿=CR?5¿-, -CR?4¿=CR?5¿-O-, -N=CR?4¿-S-, -S-CR?4¿=N-, -NR?6¿-CR?4¿=CR?5¿- et -CR?4¿=CR?5¿-NR?6¿-; ou un sel de ces dérivés acceptable dans le domaine pharmaceutique ou un ester de ceux-ci hydrolysable in vivo ; (avec des conditions) ; possèdent une activité inhibitrice de glycogène phosphorylase. Ils sont par conséquent utiles pour le traitement de maladies liées à une activité accrue de glycogène phosphorylase. Des procédés de fabrication desdits dérivés d'amides hétérocycliques ainsi que des compositions pharmaceutiques qui en contiennent sont décrits.

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