C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
C12N 15/40 (2006.01) A61K 39/00 (2006.01) C07K 14/02 (2006.01) C07K 14/08 (2006.01) C07K 14/12 (2006.01) C07K 14/145 (2006.01) C12N 7/01 (2006.01) C12N 15/62 (2006.01) C12N 15/82 (2006.01)
Patent
CA 2387626
The present invention relates to the expression of peptides on viral particles, and more particularly to the expression of peptides on the interior of the viral capsid. Methods are described for modifying viruses so that exogenous epitopes are expressed on the interior of the viral capsid. Viruses that can be modified include (+) stranded RNA viruses, especially plant (+) stranded RNA viruses such as the cowpea mosaic virus. Internal expression is especially useful for the expression of hydrophobic epitopes. The modified viral particles also find use as vaccines and as such are capable of eliciting an immune response.
L'invention concerne l'expression de peptides sur des particules virales, et plus particulièrement l'expression de peptides sur l'intérieur de la capside virale. Des procédés décrits permettent de modifier des virus de manière à obtenir l'expression d'épitopes exogènes sur l'intérieur de la capside virale. Les virus pouvant être modifiés comprennent des virus à ARN à brin codant, spécialement des virus à ARN à brin codant végétaux tels que le <= cowpea mosaic virus >= (CPMV). L'expression interne est particulièrement utile en vue de l'expression d'épitopes hydrophobes. Les particules virales modifiées peuvent aussi être utilisées comme vaccins, et dans ce cas sont capables de déclencher une réaction immunitaire.
Hellendoorn Koen
Jones Tim
Smart & Biggar
The Dow Chemical Company
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