Use of derivatives of imidazo[1, 2-a]pyridine-2-carboxamides...

Details Use of derivatives of imidazo[1, 2-a]pyridine-2-carboxamides... Use of derivatives of imidazo[1, 2-a]pyridine-2-carboxamides...

A - Human Necessities

61

K

A61K 31/454 (2006.01)

Patent

CA 2656363

The invention relates to the use of compounds having formula (I), in which: R1, R2, R3 and R4 are hydrogen and X is a phenyl group that is optionally substituted by one or more groups selected independently from among the atoms and groups comprising halogen, (C1-C6)alkoxy, (C1-C6)alkyl, cyclo(C1-C6)alkyl(C1-C6)alkyl, cyclo(C1-C6)alkyl(C1-C6)alkoxy and NRaRb; or R2 is chlorine and X is a para-fluoro-phenyl; or R3 is a methyl and X is a non-substituted phenyl group; or R1 is a methly and X is a non-substituted phenyl group; and Ra and Rb are, independently of each other, hydrogen, (C1-C6)alkyl or together with the nitrogen atom form a 4-7-link ring, said compounds taking the form of a base or an acid addition salt. The invention is intended for the preparation of a medicament for the treatment and prevention of diseases involving the NOT receptor.

L'utilisation de composés répondant à la formule (I), dans laquelle R1, R2, R3 et R4 sont hydrogène et X un groupe phényle éventuellement substitué par un ou plusieurs groupes choisis indépendamment les uns des autres parmi les atomes ou groupes suivants halogène, (C1-C6)alcoxy, (C1-C6)alkyle, cyclo(C1-C6)alkyle(C1-C6)alkyle, cyclo(C1-C6)alkyle(C1-C6)alcoxy, NRaRb; ou R2 est chlore et X est un para-fluoro-phényle; ou R3 est un méthyle et X est un groupe phényle non substitué; ou R1 est un méthyle et X est un groupe phényle non substitué, Ra et Rb sont indépendamment l'un de l'autre, hydrogène, (C1-C6)alkyle ou forment avec l'atome d'azote un cycle de 4 à 7 chaînons, à l'état de base ou de sel d'addition à un acide pour la préparation d'un médicament pour le traitement et la prévention des maladies dans lesquelles le récepteur NOT est impliqué.

Affiliated with

Also associated with

Rating

Use of derivatives of imidazo[1, 2-a]pyridine-2-carboxamides... does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Use of derivatives of imidazo[1, 2-a]pyridine-2-carboxamides..., we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Use of derivatives of imidazo[1, 2-a]pyridine-2-carboxamides... will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFCA-PAI-O-1761650