Combination therapy using cox-2 selective inhibitor and...

A - Human Necessities – 61 – K

Patent

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A61K 45/06 (2006.01) A61K 31/365 (2006.01) A61K 31/415 (2006.01) A61K 31/42 (2006.01) A61K 31/444 (2006.01) A61P 1/02 (2006.01) A61P 7/02 (2006.01) A61P 9/00 (2006.01) A61P 9/10 (2006.01) A61P 11/00 (2006.01) A61P 15/08 (2006.01) A61P 17/02 (2006.01) A61P 19/00 (2006.01) A61P 19/02 (2006.01) A61P 19/06 (2006.01) A61P 21/00 (2006.01) A61P 25/02 (2006.01) A61P 25/04 (2006.01) A61P 25/06 (2006.01) A61P 25/28 (2006.01) A61P 29/00 (2006.01) A61P 31/12 (2006.01) A61P 31/16 (2006.01) A61P 35/00 (2006.01) A61P 43/0

Patent

CA 2407469

The present invention provides a method for the treatment or prophylaxis of COX-2 mediated conditions in patients who are at risk of developing thromboembolic events which comprises administering to said patient a therapeutically or prophylactically effective amount of a COX-2 selective inhibitor and a cardiovascular protective amount of a thromboxane inhibitor, as well as compositions therefor.

L'invention concerne un procédé de traitement ou de prophylaxie de conditions pathologiques à médiation de COX-2 chez des patients présentant le risque de développer des complications thromboemboliques, qui comprend l'administration à ces patients d'une dose efficace du point de vue thérapeutique ou prophylactique d'un inhibiteur sélectif de COX-2 et d'une quantité protectrice du point de vue cardio-vasculaire d'un inhibiteur de la thromboxane. L'invention concerne également des compositions contenant ces inhibiteurs.

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