Compositions and methods for the treatment of parkinson's...

Details Compositions and methods for the treatment of parkinson's... Compositions and methods for the treatment of parkinson's...

A - Human Necessities

61

K

A61K 31/47 (2006.01)

Patent

CA 2531810

This invention provides compositions and methods for increasing cellular respiration of melanized catecholamine neurons, and methods for alleviating symptoms or stopping appearance and/or progression of symptoms of Parkinson's disease and related conditions, characterized by nigrostriatal degeneration, as well as drug-induced dyskinesias, tardive dyskinesia, Neuroleptic Malignant Syndrome, and negative symptoms of schizophrenia. An effective amount of a neuromelanin-binding composition having a quinoline ring in a suitable pharmaceutical carrier is administered to patient in need of such treatment. Preferably the composition comprises (-)-chloroquine diphosphate. Selected adjuvants are also provided as part of the compositions of this invention.

L'invention concerne des compositions et des procédés pour améliorer la respiration cellulaire des neurones produisant de la catécholamine mélanisée, et des procédés pour trouver les symptômes ou stopper l'apparence et/ou la progression des symptômes de la maladie de Parkinson et des états pathologiques associés. L'invention est caractérisée par la dégénérescence nigro-striée, ainsi que la dyskinésie induite par les médicaments, une diskynésie tardive, un syndrome malin neuroleptique, et des symptômes négatifs de la schizophrénie. Une quantité efficace d'une composition de liaison de la neuromélanine présentant un noyau de quinoline dans une porteuse pharmaceutiquement acceptable est administrée à un patient qui a besoin d'un tel traitement. De préférence, la composition comprend (-)-chloroquine diphosphate. L'invention concerne également des additifs sélectionnés en tant que partie des compositions de l'invention.

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