Modified oligonucleotides, their preparation and their use

Details Modified oligonucleotides, their preparation and their use Modified oligonucleotides, their preparation and their use

C - Chemistry, Metallurgy

12

Q

C12Q 1/70 (2006.01) A61K 31/70 (2006.01) A61K 48/00 (2006.01) C07H 19/056 (2006.01) C07H 19/20 (2006.01) C07H 21/00 (2006.01) C12N 15/11 (2006.01) C12Q 1/68 (2006.01)

Patent

CA 2148312

The invention relates to novel modified oligonucleotides which contain at least one 8-azapurine base and form more stable hybridization complexes with nucleic acids; To a process for their preparation, and to their use as inhibitors of gene expression, as probes for detecting nucleic acids, as aids in molecular biology, and as a pharmaceutical or diagnostic agent.

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