C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
C12N 15/30 (2006.01) A61K 39/005 (2006.01) C07K 7/06 (2006.01) C07K 7/08 (2006.01) C07K 14/44 (2006.01) G01N 33/569 (2006.01) A61K 38/00 (2006.01) A61K 39/00 (2006.01)
Patent
CA 2215104
Compounds and methods for diagnosing Trypanosoma cruzi infection, or for screening for T. cruzi or Leishmania infection, are disclosed. The disclosed compounds are polypeptides, or antibodies thereto, that contain one or more antigenic epitopes of T. cruzi proteins. The compounds are useful in a variety of immunoassays for detecting T. cruzi infection. The polypeptide compounds are further useful in vaccines and pharmaceutical compositions for preventing Chagas' disease in individuals exposed to T. cruzi.
Composés et méthodes de diagnostic de l'infection par Trypanosoma cruzi ou de dépistage de cette infection ou de la Leishmaniose. Les composés en question sont des polypeptides ou des anticorps de ces polypeptides, qui renferment un ou plusieurs épitopes antigène des proteines de Trypanosoma cruzi. Ces composés sont utiles dans toute une serie de dosages immunologiques de dépistage de l'infection par Trypanosoma cruzi. Ces composés polypeptides se révèlent en outre utiles dans des vaccins et des compositions pharmaceutiques de prévention de la maladie de Chagas chez les personnes exposées à Trypanosoma cruzi.
Houghton Raymond L.
Reed Steven G.
Corixa Corporation
Gowling Lafleur Henderson Llp
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