Bodily fluid markers of tissue hypoxia

G - Physics – 01 – N

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Details

G01N 33/68 (2006.01) G01N 33/577 (2006.01)

Patent

CA 2507415

The present invention provides a method and kit for screening, diagnosis or prognosis of tissue hypoxia or of a clinical syndrome indicative of tissue hypoxia in a mammalian subject, for determining the stage or severity of tissue hypoxia or of a clinical syndrome indicative of tissue hypoxia in a mammalian subject, for identifying a mammalian subject at risk of developing tissue hypoxia or a clinical syndrome indicative of tissue hypoxia, or for monitoring the effect of therapy administered to a mammalian subject having tissue hypoxia or a clinical syndrome indicative of tissue hypoxia. The level of oxygen regulated protein (ORP150) or a fragment thereof in a sample of bodily fluid from said mammalian subject is measured to provide information as regards the tissue hypoxia or clinical syndrome indicative of tissue hypoxia.

Cette invention se rapporte à un procédé et à un kit pour le dépistage, diagnostic ou pronostic de l'hypoxie tissulaire ou d'un syndrome clinique indiquant une hypoxie tissulaire chez un sujet mammifère, pour déterminer la phase ou la gravité de l'hypoxie tissulaire ou d'un syndrome clinique indiquant une hypoxie tissulaire chez un sujet mammifère, pour identifier un sujet mammifère risquant de développer une hypoxie tissulaire ou un syndrome clinique indiquant une hypoxie tissulaire, ou pour suivre l'effet d'une thérapie administrée à un sujet mammifère soufrant d'hypoxie tissulaire ou d'un syndrome clinique indiquant une hypoxie tissulaire. Le niveau de la protéine régulée par oxygène (ORP150) ou d'un fragment de celle-ci dans un échantillon de fluide corporel provenant de ce sujet mammifère est mesuré pour fournir des informations concernant l'hypoxie tissulaire ou un syndrome clinique indiquant une hypoxie tissulaire.

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