Targeted chromosomal genomic alterations with modified...

Details Targeted chromosomal genomic alterations with modified... Targeted chromosomal genomic alterations with modified...

C - Chemistry, Metallurgy

12

N

C12N 15/10 (2006.01) A01K 67/027 (2006.01) A61K 31/7088 (2006.01) A61K 48/00 (2006.01) C07H 21/04 (2006.01) C12N 5/10 (2006.01) C12N 15/11 (2006.01) A61K 38/00 (2006.01)

Patent

CA 2404780

Presented are methods and compositions for targeted chromosomal genomic alterations using modified single-stranded oligonucleotides. The oligonucleotides of the invention have at least one modified single-stranded oligonucleotides. The oligonucleotides of the invention have at least one modified nuclease-resistant terminal region comprising phophorothioate linkages, LNA analogs or 2'-O-Me base analogs.

L'invention concerne des procédés et des compositions destinés à des altérations génomiques chromosomiques ciblées utilisant des oligonucléotides monocaténaires modifiés. Ces oligonucléotides de l'invention possèdent au moins un oligonucléotide monocaténaire modifié. Ils possèdent au moins une région terminale modifiée résistant à la nucléase comprenant des liaisons phophorothioates, des analogues ANL ou des analogues de base de 2'-O-Me.

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