C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
C12N 15/13 (2006.01) A61K 47/48 (2006.01) C07K 14/705 (2006.01) C07K 14/725 (2006.01) C07K 14/73 (2006.01) C07K 14/735 (2006.01) C07K 14/74 (2006.01) C07K 16/00 (2006.01) C07K 16/46 (2006.01) C07K 19/00 (2006.01) C12N 1/21 (2006.01) C12N 15/62 (2006.01) C12N 15/70 (2006.01)
Patent
CA 2118508
2118508 9322332 PCTABS00027 Disclosed are recombinant vectors encoding immunoglobulin-like domains and portions thereof, such as T-cell variable domains, antidoby Fc-hinge fragments, subfragments and mutant domains with reduced biological half lives. Methods of producing large quantities of such domains, heterodimers, and fusion proteins following expression and secretion by prokaryotic host cells are also reported. Described are single chain T-cell receptors, which are folded into .beta.-pleated sheet structures similar to those of immunoglobulin variable domains; antibody Fc and Fc-hinge domains, which have the same in vivo stability as intact antibodies; and domains engineered to have reduced in vivo half lives. These DNA constructs and protein domains will be useful as templates for in vitro mutagenesis and high resolution structural studies; for immunization and vaccination; and for the production of recombinant antibodies or chimaeric proteins with increased or decreased stability and longevity for therapeutic and diagnostic uses.
Kim Jin-Kyoo
Ward Elizabeth S.
Bereskin & Parr
The Board Of Regents Of The University Of Texas System
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