New effector conjugates, process for their production and...

Details New effector conjugates, process for their production and... New effector conjugates, process for their production and...

C - Chemistry, Metallurgy

07

D

C07D 513/04 (2006.01) A61K 31/427 (2006.01) A61K 47/48 (2006.01) C07C 323/24 (2006.01) C07D 207/40 (2006.01) C07D 405/06 (2006.01) C07D 413/04 (2006.01) C07D 413/06 (2006.01) C07D 417/04 (2006.01) C07D 417/06 (2006.01) C07D 417/14 (2006.01) C07D 493/04 (2006.01) C07D 498/04 (2006.01)

Patent

CA 2492437

Conjugates of epothilones and epothilone derivatives (as effectors) with suitable biomolecules (as recognition units) are described. Their production is carried out by the effectors being reacted with suitable linkers, and the compounds that are produced are conjugated to the recognition units. The pharmaceutical use of the conjugates for treating proliferative or angiogenesis-associated processes is described.

L'invention concerne des conjugués d'épothilones et des dérivés d'épothilone (en tant qu'effecteurs) avec des biomolécules adéquates (en tant qu'unités de reconnaissance). Le procédé de production consiste à faire réagir les effecteurs avec des lieurs appropriés ; les composés qui sont produits étant conjugués avec les unités de reconnaissance. La présente invention concerne également l'utilisation pharmaceutique de ces conjugués pour traiter des troubles prolifératifs ou associés à l'angiogenèse.

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