C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
C12N 15/12 (2006.01) A61K 38/17 (2006.01) C07K 14/47 (2006.01) C07K 14/81 (2006.01) A61K 38/00 (2006.01)
Patent
CA 2426102
The present invention is directed to novel polypeptides having sequence similarity to human inter-alpha-trypsin inhibitor and to nucleic acid molecules encoding those polypeptides. Also provided herein are vectors and host cells comprising those nucleic acid sequences, chimeric polypeptide molecules comprising the polypeptides of the present invention fused to heterologous polypeptide sequences, antibodies which bind to the polypeptides of the present invention and to methods for producing the polypeptides of the present invention. Further provided herein are methods of using the polypeptide to diagnose and treat damage to cartilage resulting from injury and/or cartilaginous disorders.
L'invention à trait à de nouveaux polypeptides qui présentent une similarité de séquences avec l'inhibiteur humain inter-alpha de la trypsine, et à des molécules d'acide nucléique codant pour ces polypeptides. L'invention concerne également des vecteurs et des cellules hôtes contenant ces séquences d'acide nucléique, des molécules polypeptidiques chimères comprenant lesdits polypeptides fusionnés à des séquences polypeptidiques hétérologues, des anticorps qui se lient auxdits polypeptides et des procédés de production de ces polypeptides. L'invention concerne en outre des procédés d'utilisation des polypeptides pour diagnostiquer et traiter des lésions cartilagineuses résultant de blessures et/ou d'affections cartilagineuses.
Filvaroff Ellen
Goddard Audrey
Grimaldi J. Christopher
Wood William I.
Dennison Associates
Genentech Inc.
LandOfFree
Method of diagnosing and treating cartilaginous disorders does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Method of diagnosing and treating cartilaginous disorders, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Method of diagnosing and treating cartilaginous disorders will most certainly appreciate the feedback.
Profile ID: LFCA-PAI-O-1765637