New polymorphs of olanzapine hydrochloride

Details New polymorphs of olanzapine hydrochloride New polymorphs of olanzapine hydrochloride

C - Chemistry, Metallurgy

07

D

C07D 495/04 (2006.01) A61K 31/551 (2006.01) A61P 25/18 (2006.01)

Patent

CA 2522734

The present invention relates to new crystalline forms I, II and III of 2- methyl-4-(4-methylpiperazin-l-yl)-10H-thieno[2,3-b] [1,5]-benzodiazepine hydrochloride, a process for the preparation thereof and pharmaceutical compositions containing the same. Said new polymorphic forms are useful as active ingredients for the treatment of psychotic conditions.

La présente invention concerne de nouvelles formes cristallines I, II et III du chlorhydrate de 2-méthyl-4-(4-méthylpipérazine-l-yl)-10H-thieno[2,3-b] [1,5]-benzodiazépine; une méthode de préparation desdites formes et des compositions pharmaceutiques contenant ces formes. Les nouvelles formes polymorphes de l'invention sont utiles comme ingrédients actifs pour le traitement d'états psychotiques.

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