Gene therapy delivery system for targeting to endothelia

Details Gene therapy delivery system for targeting to endothelia Gene therapy delivery system for targeting to endothelia

A - Human Necessities

61

K

A61K 48/00 (2006.01) A61K 9/16 (2006.01) A61K 9/51 (2006.01) A61K 31/70 (2006.01) A61K 47/36 (2006.01) A61K 47/48 (2006.01) C12N 15/88 (2006.01)

Patent

CA 2257300

A composition comprising biodegradable microspheres that act as carriers for the delivery of DNA to the endothelial cells of a vascular bed, wherein the microspheres carry a net negative charge and to which is adsorbed positively charged particles of a smaller size, wherein such positively charged particles comprise a conjugate of DNA and a cationic compacting agent.

La présente invention a pour objet une composition contenant des microsphères biodégradables faisant office de véhicules pour l'apport d'ADN aux cellules endothéliales d'un réseau vasculaire, dans laquelle les microsphères portent une charge négative nette, des particules à charge positive de taille plus petite étant adsorbées sur lesdites microsphères, et lesdites particules comprenant un conjugué d'ADN et d'un agent de compression cationique.

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