C - Chemistry – Metallurgy – 07 – F
Patent
C - Chemistry, Metallurgy
07
F
C07F 9/655 (2006.01) A61K 31/66 (2006.01) C07F 9/6558 (2006.01)
Patent
CA 2207656
Compounds represented by general formula (I) or pharmacologically acceptable salts thereof; remedies for thrombocytopenia containing the same as the active ingredient; intermediates for the synthesis of the same; and a process for producing the same, wherein R represents -NHCHR1R2, -N(CHR1R2)2, - N(CHR1R2)CHR3R4, -N+(CHR1R2)3, -N+(CHR1R2)2CHR3R4 or -N+(CHR1R2)(CHR3R4)CHR5R6 (wherein R1, R2, R3, R4, R5 and R6 represent each hydrogen, etc., or CHR1R2, CHR3R4 or CHR5R6 may form cyclic alkyl).
La présente invention concerne des composés représentés par la formule générale (1) ou certains de leurs sels pharmacologiquement admis. L'invention concerne également des médicaments contre la thrombopénie et dont le principe actif est l'un de ces composés ou sels. L'invention concerne en outre des intermédiaires pour leur synthèse. L'invention concerne enfin un procédé de production correspondant. Dans cette formule, R représente -NHCHR¿1?R¿2?, -N(CHR¿1?R¿2?)¿2?, -N(CHR¿1?R¿2?)CHR¿3?R¿4?, -N?+¿(CHR¿1?R¿2?)¿3?, -N?+¿(CHR¿1?R¿2?)¿2?CHR¿3?R¿4? ou -N?+¿(CHR¿1?R¿2?)(CHR¿3?R¿4?)CHR¿5?R¿6? (R¿1?, R¿2?, R¿3?, R¿4?, R¿5? et R¿6? représentant chacun hydrogène, etc., ou CHR¿1?R¿2?, CHR¿3?R¿4? ou CHR¿5?R¿6? pouvant former un alkyle cyclique).
Haruyama Munetada
Hashino Junko
Iwasawa Norio
Kitajima Yasuo
Miura Kenju
Daiichi Suntory Pharma Co. Ltd.
Ogilvy Renault Llp/s.e.n.c.r.l.,s.r.l.
Suntory Limited
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