Tertiary amine substituted peptides useful as inhibitors of...

Details Tertiary amine substituted peptides useful as inhibitors of... Tertiary amine substituted peptides useful as inhibitors of...

C - Chemistry, Metallurgy

07

K

C07K 5/08 (2006.01) A61K 38/06 (2006.01) A61P 31/14 (2006.01)

Patent

CA 2679377

The present invention provides tertiary amine substituted peptides of Formula (I) useful as inhibitors of HCV replication. The variables R and R1-R12 in Formula I are described herein. The invention also includes methods for preparing such compounds. The present invention further includes pharmaceutical compositions containing tertiary amine substituted peptides and methods for using such compounds, including methods for using the compounds to treat hepatitis C infection.

L'invention concerne des peptides substitués par une amine tertiaire représentés par la formule (I), qui sont utiles comme inhibiteurs de la réplication du virus de l'hépatite C. Les variables R et R1-R12 dans la formule I sont décrits dans le descriptif. L'invention comprend aussi des procédés de préparation de tels composés ; des compositions pharmaceutiques contenant des peptides substitués par une amine tertiaire et des procédés d'utilisation de tels composés, y compris des procédés d'utilisation de ces composés dans le traitement d'une infection par le virus de l'hépatite C.

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