Targeted delivery of drugs for the treatment of parasitic...

Details Targeted delivery of drugs for the treatment of parasitic... Targeted delivery of drugs for the treatment of parasitic...

A - Human Necessities

61

K

A61K 47/48 (2006.01) A61P 33/02 (2006.01) G01N 33/68 (2006.01)

Patent

CA 2447395

Conjugates of transferrin or transcobalamin with anti-protozoan drugs are useful in the treatment of protozoan infections. Suitable anti-protozoan drugs include apoptosis inducing compounds, a cytotoxic antibiotic, an alkalating agent, a plant toxin, and a bacterial mutant toxin. Transferrin or transcobalamin is preferably coupled to the anti-protozoan drug by means of glutaraldehyde.

Des conjugués de transferrine ou de transcobalamine avec des médicaments anti-protozoaires sont utiles dans le traitement d'infections à protozoaires. Des médicaments anti-protozoaires appropriés comprennent des composés entraînant l'apoptose, un antibiotique cytotoxique, un agent contre alcalinisant, une phytotoxine, et une toxine bactérienne mutante. La transferrine ou la transcobalamine est associée de préférence au médicament antiprotozoaire au moyen de glutaraldéhyde.

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