Process of making substituted pyrazoles

Details Process of making substituted pyrazoles Process of making substituted pyrazoles

C - Chemistry, Metallurgy

07

D

C07D 231/12 (2006.01) C07D 231/38 (2006.01) C07D 401/04 (2006.01)

Patent

CA 2387762

Disclosed is a process of making substituted pyrazoles (1) from substituted benzophenone hydrazones (11) with a variety of 13-bifunctional substrates (III) under acid conditions. The pyrazole compounds are useful for making pharmaceutical compounds. In said formula, wherein X is chosen from -CN and -C(O)-R3 wherein if X is CN then R3 in the product formula (I) is amino.

On décrit un procédé de production de pyrazoles substitués (I) à partir de benzophénone hydrazones substitués (II) avec une diversité de substrats 1,3-bifunctionnels (III) dans des conditions acides. Les composés pyrazole sont utiles pour préparer des composés pharmaceutiques. Dans la formule, X est sélectionné entre -CN et -C(O)-R3 et si X représente CN alors R3, dans la formule (I) représente amino.

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