Pyrazole compounds useful as protein kinase inhibitors

Details Pyrazole compounds useful as protein kinase inhibitors Pyrazole compounds useful as protein kinase inhibitors

C - Chemistry, Metallurgy

07

D

C07D 403/12 (2006.01) A61K 31/506 (2006.01) A61K 31/517 (2006.01) A61K 31/519 (2006.01) C07D 401/14 (2006.01) C07D 409/14 (2006.01) C07D 417/14 (2006.01) C07D 471/04 (2006.01)

Patent

CA 2432799

This invention describes novel pyrazole compound of formula (IIc): wherein R1 is T-Ring D, wherein Ring D is a 5-7 membered monocyclic ring or 8-10 membered bicyclic ring selected from aryl, heteroaryl, heterocyclyl or carbocyclyl; Rx and Ry are taken together with their intervening atoms to form a fused, unsaturated or partially unsaturated, 5-7 membered ring having 0-3 heteroatoms; and R2 and R2' are as described in the specification. The compounds are useful as protein kinase inhibitors, especially as inhibitors of Aurora-2 and GSK-3, for treating diseases such as cancer, diabetes and Alzheimer's disease.

La présente invention traite de nouveaux composés de pyrazole selon la formule IIc. Dans cette dernière, R?1¿ est une T-(chaîne D) où la chaîne D est une chaîne monocyclique de 5 à 7 éléments ou un chaîne bicyclique de 8 à 10 éléments sélectionnés parmi de l'aryle, hétéroaryle, hétérocyclyle ou carbocyclyle ; R?x¿ et R?y¿ sont pris ensemble avec leurs atomes intermédiaires pour former un chaîne fondue non saturée ou partiellement non saturée, de 5 à 7 éléments avec 0 3 hétéroatomes et R?2¿ et R?2'¿ sont tels que définis dans le descriptif. Ces composés sont utiles comme inhibiteurs de protéine kinase, en particulier, comme inhibiteurs de Aurora-2 et GSK-3, pour traiter des maladies comme le cancer, le diabète et la maladie d'Alzheimer.

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