Nucleic acid and corresponding protein entitled 184p1e2...

Details Nucleic acid and corresponding protein entitled 184p1e2... Nucleic acid and corresponding protein entitled 184p1e2...

C - Chemistry, Metallurgy

12

N

C12N 15/12 (2006.01) A01K 67/027 (2006.01) A61K 31/7088 (2006.01) A61K 38/17 (2006.01) A61K 39/395 (2006.01) A61K 47/48 (2006.01) A61K 48/00 (2006.01) A61P 35/00 (2006.01) C07K 14/47 (2006.01) C07K 16/18 (2006.01) C07K 16/30 (2006.01) C12N 5/12 (2006.01) C12N 15/62 (2006.01) C12Q 1/00 (2006.01) C12Q 1/02 (2006.01) C12Q 1/68 (2006.01) G01N 33/53 (2006.01) G01N 33/574 (2006.01)

Patent

CA 2443147

A novel gene (designated 184P1E2) and its encoded protein, and variants thereof, are described wherein 184P1E2 exhibits tissue specific expression in normal adult tissue, and is aberrantly expressed in the cancers listed in Table I. Consequently, 184P1E2 provides a diagnostic, prognostic, prophylactic and/or therapeutic target for cancer. The 184P1E2 gene or fragment thereof, or its encoded protein, or variants thereof, or a fragment thereof, can be used to elicit a humoral or cellular immune response; antibodies or T cells reactive with 184P1E2 can be used in active or passive immunization.

La présente invention concerne un nouveau gène (appelé 184P1E2) et sa protéine codée, et des variants correspondants. Ce gène 184P1E2 présente une expression tissulaire spécifique dans un tissu adulte normal et il est exprimé de manière abérrante dans les cancers répertoriés dans le tableau 1. Par conséquent, ce gène engendre une cible diagnostique, prognostique, prophylactique et/ou thérapeutique pour le cancer. On peut utiliser le gène184P1E2 ou un fragment correspondant ou sa protéine codée ou des variants correspondants ou un fragment correspondant pour provoquer une réponse immunitaire cellulaire ou humorale. En outre, on peut utiliser des anticorps ou des cellules T réactives au gène 184P1E2 dans une immunisation active ou passive.

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