Piperidine compounds and a pharmaceutical composition

Details Piperidine compounds and a pharmaceutical composition Piperidine compounds and a pharmaceutical composition

C - Chemistry, Metallurgy

07

D

C07D 409/04 (2006.01) A61K 31/445 (2006.01) C07D 401/04 (2006.01) C07D 405/04 (2006.01) C07D 405/14 (2006.01) C07D 409/14 (2006.01)

Patent

CA 2071480

2071480 9109032 PCTABS00005 Novel piperidine compounds having formula (I), wherein R3 is 3,4-methylenedioxyphenyl, phenyl, naphtyl, which are optionally substituted with one or two halogen, amino, C1-6-alkyl mono- or disubstituted amino group, C1-6-alkoxy, cyano, mono-, di- or trihalogenated C1-6-alkyl, C2-6-alkenyl, C1-6-alkyl, C3-5-alkylene, trifluoromethoxy, or trifluoromethyl groups, R1 is hydrogen, straight or branched C1-8-alkyl, C1-8-alkoxy-C1-8-alkyl, C3-8-cycloalkyl, C2-6-alkenyl, C4-8-cycloalkylalkyl, C2-6-alkynyl, Z is hydrogen, straight or branched C1-8-alkyl, Y is O or S, X is O, S or NR, wherein R is hydrogen or C1-4-alkyl or a salt thereof with a pharmaceutically acceptable acid. The novel compounds are useful in the treatment of anoxia, traumatic injury, ischemia, migraine and epilepsy.

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