Method for identifying pde11 modulators

Details Method for identifying pde11 modulators Method for identifying pde11 modulators

C - Chemistry, Metallurgy

12

N

C12N 9/88 (2006.01) C12N 5/10 (2006.01) C12N 15/60 (2006.01) C12N 15/62 (2006.01) C12Q 1/48 (2006.01)

Patent

CA 2598593

The invention relates to a novel GAF A domain-containing polypeptide, to the GAF A domain of a human phosphodiesterase 11 (PDE11) and to the adenylate cyclase catalytic domain. The use of said polypeptide in a method for identifying PDE11-modulators is also disclosed.

L'invention concerne un nouveau polypeptide, contenant le domaine GAF<SUB>A</SUB> et le domaine GAF<SUB>B</SUB> d'une phosphodiestérase 11 (PDE11) humaine ainsi que le domaine catalytique d'une adénylate cyclase. Elle concerne également l'utilisation de ce polypeptide dans une méthode d'identification de modulateurs de PDE11.

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