A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 39/395 (2006.01) A61K 38/39 (2006.01) C07K 16/28 (2006.01)
Patent
CA 2360146
The present invention describes methods for inhibition of tumor growth in the brain, using antagonists of integrins such as .alpha.v.beta.3 and .alpha.v.beta.5. Antagonists of the present invention can inhibit angiogenesis in brain tumor tissue. They can also inhibit vitronectin and tenascin-mediated cell adhesion and migration in brain tumor cells. They can further induce direct brain tumor cell death.
Cette invention concerne des procédés qui permettent d'inhiber la croissance de tumeurs dans le cerveau, ceci à l'aide d'antagonistes d'intégrines tels qu'un .alpha.¿v?.beta.¿3? et un .alpha.¿v?.beta.¿5?. Les antagonistes décrits dans cette invention sont capables d'inhiber l'angiogenèse dans les tissus de tumeurs cérébrales. Ils peuvent également inhiber l'adhérence cellulaire induite par la tenascine et la vitronectine et la migration dans les cellules de tumeurs cérébrales. Ces antagonistes peuvent en outre induire la mort directe de cellules de tumeurs cérébrales.
Cassan Maclean
Children's Hospital Los Angeles
LandOfFree
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