Synthesis of gatifloxacin

Details Synthesis of gatifloxacin Synthesis of gatifloxacin

C - Chemistry, Metallurgy

07

D

C07D 401/04 (2006.01) C07D 215/56 (2006.01)

Patent

CA 2495271

Provided is a method for making (.plusmn.)-1-Cyclopropyl-6-fluoro-1,4-dihydro- 8-methoxy-7-(3-methyl-1-piperazinyl)-4-oxo-3-quinolenecarboxylic acid, commonly known as gatifloxacin, in very high purity, in a suspension in a dipolar aprotic solvent.

L'invention concerne un procédé de fabrication d'acide (.plusmn.)-1-cyclopropyl-6-fluoro-1,4-dihydro-8-méthoxy-7-(3-méthyl-1-pipérazinyl)-4-oxo-3-quinolènecarboxylique, communément appelé gatifloxacine, sous une forme très pure, dans une suspension de solvant aprotique dipolaire.

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