New 4-amino-4-oxobutanoyl peptides as inhibitors of viral...

Details New 4-amino-4-oxobutanoyl peptides as inhibitors of viral... New 4-amino-4-oxobutanoyl peptides as inhibitors of viral...

C - Chemistry, Metallurgy

07

D

C07D 403/14 (2006.01) A61K 31/437 (2006.01) A61P 31/12 (2006.01) C07D 413/14 (2006.01)

Patent

CA 2746264

The invention provides 4-amino-4-oxobutanoyl peptides of Formula I and the pharmaceutically salts and hydrates thereof. The variables R, R1, R6-R8, R16, R18, R19, M, n, T, Y, and Z are defined herein. Certain compounds of Formula I are useful as antiviral agents. The 4-amino-4-oxobutanoyl peptides disclosed herein are potent and/ or selective inhibitors of viral replication, particularly Hepatitis C virus replication. The invention also provides pharmaceutical compositions containing one or more 4-amino-4-oxobutanoyl peptides and one or more pharmaceutically acceptable carriers. Such pharmaceutical compositions may contain a 4-amino-4-oxobutanoyl peptides as the only active agent or may contain a combination of a 4-amino-4-oxobutanoyl peptides and one or more other pharmaceutically active agents. The invention also provides methods for treating viral infections, including Hepatitis C infections.

La présente invention des peptides 4-amino-4-oxobutanoyl représentés par la formule I ainsi que leurs sels et hydrates pharmaceutiquement acceptables. Les variables R, R1, R6-R8, R16, R18, R19, M, n, T, Y et Z sont telles que définies dans l'invention. Certains composés de formule I sont utiles en tant qu'agents antiviraux. Les peptides 4-amino-4-oxobutanoyl selon l'invention sont des inhibiteurs puissants et/ou sélectifs de la réplication virale, notamment de la réplication du virus de l'hépatite C. Cette invention porte également sur des compositions pharmaceutiques contenant un ou plusieurs peptides 4-amino-4-oxobutanoyl et un ou plusieurs véhicules pharmaceutiquement acceptables. Lesdites compositions pharmaceutiques peuvent contenir un peptide 4-amino-4-oxobutanoyl en tant qu'unique agent actif ou peuvent contenir une combinaison d'un peptide 4-amino-4-oxobutanoyl et d'un ou plusieurs agents actifs du point de vue pharmaceutique. La présente invention concerne également des méthodes de traitement des infections virales, y compris les infections provoquées par le virus de l'hépatite C.

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