N6 heterocyclic 8-modified adenosine derivatives

Details N6 heterocyclic 8-modified adenosine derivatives N6 heterocyclic 8-modified adenosine derivatives

C - Chemistry, Metallurgy

07

H

C07H 19/16 (2006.01) A61K 31/7076 (2006.01) A61P 9/00 (2006.01)

Patent

CA 2394861

N6 heterocyclic 8 modified adenosine derivatives that are selective, partial or full adenosine A1 receptor partial or full agonists, and as such, are useful for modifying cardiac activity, modifying adipocyte function, treating central nervous system disorders, and treating diabetic disorders and obesity in mammals, and especially in humans.

L'invention concerne des dérivés d'adénosine N<6> hétérocyclique modifiés en position 8, étant sélectivement des agonistes partiels ou entiers du récepteur A1 partiel ou entier de l'adénosine et, en tant que tels, sont utiles pour modifier l'activité cardiaque, la fonction de l'adipocyte, et pour traiter les troubles du système nerveux central, les troubles liés au diabète et l'obésité chez les mammifères et notamment chez l'homme.

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