A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 38/20 (2006.01) A61K 31/445 (2006.01) A61K 31/57 (2006.01) A61K 35/12 (2006.01) A61K 38/13 (2006.01) A61K 39/00 (2006.01) A61K 39/395 (2006.01) A61P 37/00 (2006.01) C07K 16/24 (2006.01) C12N 5/10 (2006.01) A61K 48/00 (2006.01)
Patent
CA 2364279
Methods for improving graft acceptance in a recipient by administration of a cytokine profile altering agent are disclosed. The methods involve biasing the cytokine response in a graft recipient to one dominated by Th2 cytokines either by increasing Th2 cytokine production or by decreasing Th1 cytokine production by administering an isolated cell and a cytokine profile altering agent to the subject to thereby promote acceptance of the graft in the subject.
La présente invention concerne un procédé d'amélioration d'acceptation de greffe chez un receveur par l'administration d'un agent modificateur du profile de la cytokine. Les procédés comprennent une modification de la réaction de la cytokine chez le receveur en la transformant en une réaction dominée par les cytokines Th2 soit en accroissant la production de la cytokine Th2 soit en réduisant la production de la cytokine Th1 par l'administration d'une cellule isolée et un agent modificateur du profile de la cytokine au sujet favorisant ainsi l'acceptation de la greffe chez un sujet.
Borden Ladner Gervais Llp
Diacrin Inc.
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