Crystalline forms of...

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C - Chemistry, Metallurgy

07

D

C07D 239/52 (2006.01) A61K 31/513 (2006.01)

Patent

CA 2584246

Crystalline forms of the p38 kinase inhibitor 3-[5-chloro-4- [(2,4~difluorobenzyl) oxy]-6-oxopyrimidin-1(6H)-yl]-N-(2-hydroxyethyl)-4- methylbenzamide is provided. Also provided are combinations and pharmaceutical compositions comprising the crystalline forms and methods for the prophylaxis and/or treatment of a p38 kinase-mediated condition comprising administering to a subject a therapeutically effective amount of the crystalline forms.

L'invention concerne des formes cristallines de l'inhibiteur de la kinase p38: 3-[5-chloro-4-[(2,4-difluorobenzyl) oxy]-6-oxopyrimidin-1(6H)-yl]-N-(2-hydroxyethyl)-4-methylbenzamide. L'invention concerne des combinaisons et des compositions pharmaceutiques comprenant ces formes cristallines, ainsi que des méthodes de prophylaxie et/ou de traitement d'un trouble médié par la kinase p38. Ces méthodes consistent à administrer à un patient, une quantité thérapeutiquement efficace de ces formes cristallines.

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