Fibrin sealant delivery method

Details Fibrin sealant delivery method Fibrin sealant delivery method

A - Human Necessities

61

K

A61K 35/14 (2006.01) A61B 17/00 (2006.01) A61K 38/48 (2006.01) A61L 24/10 (2006.01) A61B 17/22 (2006.01)

Patent

CA 2072355

The present invention relates to a method for the formulation of fibrin sealant in a single delivery system. The method involves mixing a fibrinogen/Factor XIII precipitate solution with thrombin under conditions such that thrombin clotting activity is inhibited and said mixture is applied to a body site under conditions which activate the thrombin to convert fibrinogen into fibrin sealant. A single device, syringe or container, can be used to apply the fibrin sealant formulation.

La présente invention décrit une méthode de formulation d'un cicatrisant de la fibrine par administration unique. Pour ce faire, on mélange une solution précipitée fibrinogène/Facteur XIII à de la thrombine dans des conditions qui inhibent l'activité de coagulation de cette dernière. Ledit mélange est ensuite appliqué à un site corporel dans des conditions propices à la conversion du fibrinogène en cicatrisant de la fibrine sous l'action de la thrombine. Ladite formulation peut être appliquée à l'aide d'un appareil unique, seringue ou aérosol.

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